A TECHNO-ECONOMIC NEWS MAGAZINE FOR MEDICAL PLASTICS AND PHARMACEUTICAL INDUSTRY
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Cover Story

Diabetes Disposables : Focus Insulin Delivery Systems

Diabetes is today recognised as a major lifestyle disease in the India, with the country having possibly the largest number of diabetics in the world. It’s ageing population; sedentary lifestyles, high stress levels, improper sleep and deteriorating eating habits are factors contributing to India being dubiously hailed as the world’s diabetic capital.

According to the International Diabetes Federation report of 2006, there are around 41 million diabetics in India, which is expected to rise to 70 million by the year 2025. Having reached such epidemic levels, there apparently is a need for novel agents to surface in the market, in particular the insulin market, which still offers the most widespread and effective blood sugar lowering treatment.

Insulin Market Scenario

According to the Global Insulin Market report, the global insulin market currently estimated at $ 7.5 billion, growing at a compound annual growth rate (CAGR) of 14 per cent is expected to rise to a whopping $ 14.5 billion by 2010. This is directly linked to the growing number of diabetics. This report predicts that approximately 380 million people will suffer from diabetes by 2025. Nearly one-third of total diabetes patients will be from India and China. Presently both have fledgling, but emerging insulin markets. In addition, this report estimates that 60 per cent of the insulin available in the market today is available in injectable form through syringes, pens, and pumps.

The demand of these are increasing due to the long duration of treatment, larger volumes and precise dose. Diabetes and therefore insulin remains the most important area in the application of self injecting devices.

Various insulin delivery methods includes syringes, pens, pumps, needle-free injectors and inhalers.

Recent developments in the administration of insulin include inhalable insulin, topical patches, buccal spray insulin, and nasal/intranasal spray formulations.

Insulin syringes and pumps dominate the US market.

Majority of users in Europe and Japan continue to use pen devices.

Needle-free injectors have been launched in the market decades ago, but so far, have failed to create a major impact.

Injection systems for self administration in particular pens are well established, and with the increase in their usage, demand for these devices is progressely increasing.

The Delivery devices which look like a large Pen use a Cartridge rather than a vial for the purpose. Injection pens are typically multi-dose injectors mainly used for frequent injections. The dose can be fixed or is variable depending upon the condition of the sufferer and the nature of treatment. Injection pens are used with dedicated drug cartridges and its process (needle insertion and injection) is usually performed manually.

These delivery devices use disposable needles and are used for the drugs, which require frequent drug administration for titration of dosage. Injection systems for self administration are recommended to patients using particular drug on frequent basis and when the duration of therapy is long.

These Delivery devices are re-usable as well as for a single use. They come with a refilled cartridge and are disposed of after the use.

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