|
Compatibility of Thermoplastic Polyurethanes
with Drugs for IV Sets
Table 1.Drug properties and study parameters
Results Lubrizol’s Pellethane® TPU IV sets did not
affect the pH, impurity and particulates of the drug products tested. For all
drugs tested, independent of their aqueous solubility and logP, Pellethane®TPU
sets showed very low drug sorption during infusion of the recommended
administration time, delivering more than90% of the dose. Further recirculation
of the solution in the sets beyond the recommended administration time did not
result in an increased drug absorption (for up to 4 – 24 hours) - Fig. 4.
Pellethane® TPU based IV sets performed similar or better than TPE or PVC – Fig
5, 6. In the case of pantoprazole sodium, Pellethane® TPU IV sets performed
slightly better, having lower initial sorption compared to TPE and PVC – Fig. 7.
|
Fig. 4. Drug recovery following circulation through TPU
IV sets |
Fig. 5. Drug recovery following circulation through TPE
IV sets |
|
Fig. 6. Drug recovery following circulation through PVC
IV sets |
Fig. 7. Pantoprazole recovery following circulation
through TPU, TPE and PVC IV sets |
Conclusion Lubrizol’s Pellethane® TPU based IV sets performed
similar or better than TPE or PVC, showing very low sorption for drug of
different properties: • Levofloxacin hydrochloride
• Moxifloxacin hydrochloride
• Metronidazole
• Docetaxel
• Furosemide
• Ranitidine hydrochloride
• Pantoprazole sodium In the case of pantoprazole, Pellethane® TPU IV sets
performed slightly better, having lower sorption compared to TPE (initial stage)
and PVC (entire duration). Lubrizol’s Pellethane® TPU properties and their
compatibility with drugs, make them suitable for use in intravascular
administration sets. Reference: *The United States Pharmacopeia and The
National Formulary (USP–NF) USP 39–NF 34, United States Pharmacopeial
Convention, Rockville, Maryland, 2016. |
